WHO: Ebola vaccine trials in W. Africa in January
GENEVA (AP) — The hunt for an Ebola vaccine will produce
data soon about whether two experimental vaccines are safe and could lead to
larger medical trials in West Africa by January, a top World Health
Organization official said Tuesday.
Dr Marie Paule Kieny, an assistant director general for WHO,
said clinical trials either planned or underway in Europe, Africa and the U.S.
are expected to produce preliminary safety data by December. In the meantime,
she said, governments are pushing for immediate "real-world use" of
an approved Ebola vaccine.
She told reporters Tuesday in Geneva there are two leading
candidates for a vaccine. If the vaccines are deemed safe, tens of thousands of
doses will be used in trials in West Africa beginning in January to test their
effectiveness, she said.
One of those vaccines, developed by the U.S. National
Institutes of Health and Glaxo Smith Kline from a modified chimpanzee cold virus
and an Ebola protein, is in clinical trials in the U.K. and in Mali. It will be
used in clinical trials in Lausanne, Switzerland, by the start of February.
The second front-runner, developed by the Public Health
Agency of Canada and known as VSV-EBOV, has been sent to the U.S. Walter Reed
Army Institute of Research in Maryland for testing on healthy volunteers, with
results expected by December. The next stage would be to test it more broadly,
including among those directly handling Ebola cases in West Africa.
Canada has donated 800 vials of the experimental vaccine to
WHO but the shipment was delayed by a Lufthansa pilots strike. It is now
expected to arrive in Switzerland on Wednesday for testing coordinated by the
U.N. health agency among volunteers at the University Hospital of Geneva, and
volunteers in Hamburg, Germany, and in Gabon and Kenya, Kieny said.
"These data are absolutely crucial to allow
decision-making on what dose level should go in the efficacy testing in
Africa," she said, referring to plans for the broader testing starting in
2015.
At a separate news conference, WHO spokeswoman Fadela Chaib
promised a thorough public audit of the agency's early missteps in responding
to the Ebola outbreak that has already killed over 4,500 people.
"There is certainly a wish and a will to have this
review," she said. "We know many elements need to be explained in the
future. ... WHO will do that, but in the future; now our focus is on the
response."
Source :
http://www.sfgate.com/news/article/WHO-Ebola-vaccine-trials-in-West-Africa-in-5837926.php
Analysis
of Direct and Indirect Speech :
Statement
1.
Direct
:
"These data are absolutely
crucial to allow decision-making on what dose level should go in the efficacy
testing in Africa," she said
Indirect
:
She said that these data
are absolutely crucial to allow decision-making on what dose level
should go in the efficacy testing in Africa
Analysis
:
In the indirect sentence
between reporting verb and the
reported word connected by conjunction.
2.
Direct :
"There is certainly a wish and
a will to have this review," she said
Indirect
:
She said that there was certainly a
wish and a will to had this review.
Analysis
:
We
use indirect speech,sometimes called Reported speech,to tell someone what
another person says or said.
Question
1.
Direct
:
He asked: “Does she
live in London?“
Indirect :
He
asked if she lived in London
Analysis :
Use
an indirect question in reported speech, i.e. after the interrogative or ‚whether‘
/ ‚if‘ you continue the sentence as if it were a statement
(subject-verb etc.). The auxiliary verb ‚do‘ is not used in indirect
questions.
2.
Direct
:
“Did you enjoy the party?”
Indirect :
She asked me whether I’d enjoyed the party.
Analysis :
The
tense of the verb changes as it does in reported speech but we don’t use auxiliary verbs.
The word order is the same as in an affirmative sentence.
Imperative
1.
Direct:
He
said to me, "What are you doing?"
Indirect:
He
entreated me what I was doing
Analysis :
In
order to change an imperative sentence into the indirect speech, we use a to-infinitive. A -that clause is also possible in some cases.
2.
Direct:
Farhat
said,”let us enjoy ourselves for an hour first.”
Indirect:
Farhat proposed that we should enjoy ourselves
for an hour first.
Analysis :
Let is changed imto should or might and
the reporting verb,if need be is changed into proposed.
4SA05
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